Frac-seq reveals isoform-specific recruitment to polyribosomes

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Figure 5.
Figure 5.

Alternative pre-mRNA processing alters the cis-regulatory landscape of mRNA isoforms. Intersection of the alternative portion of each significant event with predicted cis-acting RNA elements. Events whose alternative region harbors or overlaps a cis-acting element are labeled by their direction of change (positive or negative ΔΨ, polyribosomal or cytoplasmic, respectively). Premature termination codon (PTC) containing events have at least one termination codon in all three reading frames of the alternative portion of the event. Events with uORF annotations contain the start codon of the annotated upstream open reading frame. The tendency of an annotated element-containing sequence toward the cytoplasm is colored gray, while the polyribosome is dark gray. Results of a χ2 goodness-of-fit test to an even ratio are denoted as follows: (***) <0.001; (**) <0.01; (*) <0.05.

This Article

  1. Genome Res. 23: 1615-1623

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