GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 7.
Figure 7.

Terminal GC skew also confers a measure of protection against DNA methylation. The graph represents the average DNA methylation profiles of genes with and without terminal GC skew. All genes were aligned at their TTS and DNA methylation in hESCs was from Laurent et al. (2010). Genes whose TSS was located within ≤2 kb to the nearest downstream promoter were also filtered out (tandem filter) to remove any confounding effects due to the presence of a nearby protected promoter.

This Article

  1. Published in Advance July 18, 2013, doi: 10.1101/gr.158436.113 Genome Res. 23: 1590-1600

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research