GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination

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Figure 6.
Figure 6.

Clustering of Class I promoters reveals new correlations between the genetic and epigenetic landscapes of CGI promoters. (A) Average GC skew profiles for the three main Class I promoter clusters. Each panel represents relevant genetic and epigenetic profiles for each cluster, including (B) CpG density, (C) GC content, (D) DNA methylation profiles, (E) H3K4me3 profiles, and (F) first exon length (represented in a boxplot format). Color codes are as indicated.

This Article

  1. Published in Advance July 18, 2013, doi: 10.1101/gr.158436.113 Genome Res. 23: 1590-1600

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