GC skew at the 5′ and 3′ ends of human genes links R-loop formation to epigenetic regulation and transcription termination

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Figure 2.
Figure 2.

Promoter classes present distinct epigenetic signatures in hESCs. (A) DNA methylation metaplots for each of the four promoter classes over a 10-kb window centered on the TSS. The numbers of promoters in each class were as follows: Class I, 8332; Class 2, 5799; Class 3, 7968; and Class 4, 2099. (B–D) Histone modification metaplots for each promoter class for H4K20me1 (B), H3K79me2 (C), and H3K27me3 (D). (E,F) Average binding profiles for each promoter class for EZH2 (E) and RNF2 (RING1B) (F). Class-specific color codes are all identical and indicated in panel B. The y-axes in panels B through F represent arbitrary units.

This Article

  1. Published in Advance July 18, 2013, doi: 10.1101/gr.158436.113 Genome Res. 23: 1590-1600

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