Figure 1.
GC skew distinguishes four promoter classes in the human genome. (A–D) Metaplots of GC skew (red line), GC percentage (green line), and CpG observed over expected ratio (o/e; blue line) were determined for each class of promoters over a 5-kb window centered around the TSS. (E) Expression levels (RPKM) for each GC skew promoter class, as determined in H1 hESCs. (F) Top gene ontology hits for Class IV genes. The x-axis represents the P-value of enrichment after Bonferroni correction.
