Figure 6.
Developmental regulation of LMNA association of promoters important for lineage commitment. In undifferentiated adipocyte progenitors (ASCs), master regulator genes of differentiation into adipogenic and nonadipogenic lineages are tethered to LMNA and not expressed. Adipogenic differentiation results in disengagement of adipogenic loci from LMNA and their transcriptional activation. However, nonadipogenic loci remain associated with LMNA in adipocytes. These include genes important for differentiation into, e.g., osteogenic or myogenic pathways, endodermal and ectodermal lineages, as well as pluripotency-associated genes.
