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Cover Barbara McClintock's early work on epigenetic gene control involved the transposable element Suppressor Mutator (Spm). Spotted kernels have active transposition during kernel development, detected as mutations from a1 to A1, and weak (pale) expression of the A1 (anthocyanin) gene, which is under epigenetic control. In this issue a high resolution map of the maize methylome is reported, revealing widespread epigenetic control of gene expression and inheritance. (Courtesy of Cold Spring Harbor Laboratory Archives. Photo: Thomas Adams. [For details, see Regulski et al., pp. 1651–1662.])
