P-value-based regulatory motif discovery using positional weight matrices

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Figure 5.
Figure 5.

Motifs discovered in cis-regulatory modules for fly segmentation. The table lists all motifs that XXmotif reports up to an E-value of 0.5 on 54 segmentation modules responsible for patterning the anterior-posterior (AP) axis during early embryogenesis. To score conservation, multiple sequence alignments of D. melanogaster, 11 other Drosophila species, and Anopheles gambiae were supplied as input. For 18 of the 28 predicted motifs, similar literature motifs of transcription factors known to be involved in AP axis segmentation were assigned by TOMTOM (Gupta et al. 2007) or by visual inspection. Nine of the predicted motifs may describe transcription factors representing missing nodes in the transcriptional network.

This Article

  1. Genome Res. 23: 181-194

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