Figure 4.
Sites significantly affected by methylation are enriched for CpGs at two positions. Frequency of a CpG (y-axis) at positions relative to the CTCF motif (x-axis) is shown for sites with variable methylation that is associated (red) and is not associated (gray) with occupancy changes. Note that at positions 1 and 11, there is a 2.2- and 1.8-fold enrichment, respectively, for the presence of a CpG at sites where the variable methylation was not associated with occupancy. Twenty-nine percent of CTCF motifs genome-wide contain a CpG at one or both of these positions.
