Figure 3.
Mutation relation analysis. A heat map showing mutations in highly mutated genes for all 316 OV samples. Dotted-line boxes highlight concurrent nonsynonymous EMR3 and FAT3 mutations (two concurrent mutations out of five nonsynonymous mutations from EMR3 and 18 from FAT3, P = 0.0333) and mutually exclusive nonsynonymous RB1 and TP53 mutations (297 mutually exclusive mutations out of six nonsynonymous mutations from RB1 and 299 from TP53, P = 0.0141).
