Mutation mapping and identification by whole-genome sequencing

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Figure 5.
Figure 5.

Improving the genome assembly using NGS-based SNP mapping. (A) Analysis of homozygous and heterozygous SNPs in the clo m39 mutation region demonstrates abrupt changes in the frequency of heterozygous SNPs, corresponding with three distinct scaffolds. (B) Removal of the scaffolds indicated above improves the HMM log likelihood score.

This Article

  1. Published in Advance May 3, 2012, doi: 10.1101/gr.135541.111 Genome Res. 22: 1541-1548

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