Mutation mapping and identification by whole-genome sequencing

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Figure 2.
Figure 2.

Mapping of two alleles of the cloche mutant. (A) Homozygosity scoring of the clo s5 and clo m39 alleles reveals corresponding overlapping peaks on chromosome 13, where the mutation has been previously mapped. (B) Sequence pileup of the clo m39 allele confirms the previously established deletion and reveals the boundaries of the deletion interval. (C) Log likelihood scoring of the clo s5 alleles achieves a higher resolution of the mutation region with a narrower interval than the homozygosity scoring method.

This Article

  1. Genome Res. 22: 1541-1548

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