Figure 7.
Model of ADARs' effects on the biogenesis of C. elegans small RNAs. Direct (red X) and indirect (blue X) effects are indicated. In WT cells (top), ADAR binding to certain dsRNAs competes with binding by other dsRBPs, in some cases inhibiting processing (e.g., pri-miRNAs, Inverse endo-siRNA precursors), while ADAR editing (red *) inhibits processing of other RNAs (e.g., rncs-1). Indirect effects arise in mutant strains when dsRNAs normally bound or edited by ADARs (e.g., miRNAs, rncs-1) are released to compete with dsRNA in other pathways.
