Figure 4.
Many endo-siRNA loci have levels affected by both Dicer and ADARs. (A,B) Plots show change in read numbers (as % of WT) observed in the dcr-1(−/−)K39A strain compared to adr-1(−/−) (A) or adr-2(−/−) (B) strains. Points are differentiated based on the strand affected in the ADAR mutant strain (sense or antisense) and whether the affected locus gives rise to 26G endo-siRNAs. Of the 1173 loci with decreased reads in the dcr-1(−/−)K39A strain compared to WT, 299 had altered sense reads, 791 had altered antisense reads, and 99 had changes in both. (C,D) Distributions of antisense and sense reads from the Inverse and Correlated classes, differentiating reads based on length.
