Cornelia Vesely; Stefanie Tauber; Fritz J. Sedlazeck; Arndt von Haeseler; Michael F. Jantsch

Adenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1.

A small set of highly abundant miRNAs found in all biological replicates and all genotypes. Normalized read numbers of the 14 most highly abundant miRNAs in wild-type, Adarb1^−/−, and Adar^−/−, Adarb1^−/− mice are shown (n = 3). Of these miRNAs, only mmu-miRNA-130b, -17, and -143 have previously been shown to be edited (Yang et al. 2006; Landgraf et al. 2007; Kawahara et al. 2008). (*) Student's t-test, P < 0.07; (°) Student's t-test, P < 0.1.