Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus

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Figure 5.
Figure 5.

Model for the functional SNPs rs8072254 and rs1859961. The E1 enhancer within the 17q24.3 risk locus loops to the SOX9 gene. Within the E1 enhancer, the variant A allele of rs8072254 increases the binding of AR and further drives the increased enhancer activity. The variant G allele of rs1859961 decreases the binding of FOXA1 but increases the binding of AP-1. This latter increases enhancer activity. This E1 enhancer establishes a loop with the SOX9 genes in prostate cancer cells.

This Article

  1. Published in Advance June 4, 2012, doi: 10.1101/gr.135665.111 Genome Res. 22: 1437-1446

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