Epigenetic annotation of 17q24.3 risk locus. (A) The ∼3-Mb region surrounding the PCa GWAS SNP rs1859962 presents the annotated RefSeq genes, the HapMap LD blocks relative to the rs1859962 SNP. (B) A focused view of the rs1859962 LD block presenting regulatory elements, SNPs covered by the HapMap project, and the LD score is presented. LD score: (dark red) LOD = 2, D′ = 1; (light red) LOD = 2, D′ < 1; (blue) LOD < 2, D′ = 1; (white) LOD < 2. D′ < 1. (C) The H3K4me3 enrichment from the ENCODE Project (layered for multiple cell lines) and PCa cells (LNCaP and VCaP) as well as the H3K36me3 and H3K9me3 enrichment from PCa cells (LNCaP and VCaP) are presented across the 17q24.3 PCa risk LD block. (D) DNase I-seq enrichment from LNCaP cells, H3K4me1 enrichment from the ENCODE Project (layered for multiple cell lines) and PCa cells (LNCaP and VCaP), and H3K4me2 enrichment from PCa cells (LNCaP and VCaP) are indicated. (Colored boxes) Highlight the five enhancers E1–E5 defined by these histone signatures.
