Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites

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Figure 6.
Figure 6.

Heatmap of overrepresented methylated transcription factor binding motifs. The top 25 overrepresented sequence motifs for each peak category and each genomic partition are compiled into a heatmap. (Top) Transcription factors (TRANSFAC IDs) with confirmed consensus sequences. (Right) Each genomic partition with cell-type categories. (Red boxes) Transcription factor binding sites that are unique to one cell-type peak in a particular partition. Green boxes are present in two cell-type categories, teal boxes represent three categories, and blue boxes indicate presence in three or more cell-type specific categories. Gray indicates that the transcription factor is not overrepresented in the data set.

This Article

  1. Genome Res. 22: 1407-1418

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