Population-based analysis of the S. cerevisiae genome organization. To analyze structural features of the genome, we defined an optimization problem with three main components. (Top panels) A structural representation of chromosomes as flexible chromatin fibers (center), a structural representation of the nuclear architecture (left), and the scoring function quantifying the genome structure's accordance with nuclear landmark constraints (right). (Middle panels) An optimization and sampling method, which minimizes the scoring function to generate a population of genome structures that entirely satisfies all landmark constraints. (Bottom panels) The statistical analysis and comparison of structural features from the population of 3D genome structures with all the experimental data.
