Sex-biased expression, expression breadth, and X-linkage in mouse. (Barplots) Percent of mouse genes in various expression classes that are X-linked. (Dashed lines) Percent of the entire genome that is X-linked. (*) Observed values that significantly differ from the expectation based on the size of the X chromosome as determined by a permutation test; (*) P < 0.05, (**) P < 0.01, (***) P < 0.001. (A) Percent of genes with female-biased (F), male-biased (M), and unbiased (U) expression that are X-linked is shown for data from four mouse tissues. (B) Percent of genes with narrow expression (τ > 0.7) in each of four sex-limited tissues (white and black), with narrow expression in one of 25 tissues (gray), narrow expression in one of 21 non-sex-limited tissues (gray, no sex) or broad expression (τ ≤ 0.4; white) that are X-linked is plotted. Genes with testis-biased expression were identified using all testis EST libraries (testis), EST libraries from adult testis (UniGene IDs 2511 and 2547), or EST libraries from 13-d and 15-d embryonic testis (UniGene IDs 2555 and 2594). (C) Percent of X-linked broadly expressed (τ ≤ 0.4), not narrowly expressed (τ ≤0.7), or narrowly expressed (τ > 0.7) genes with either female-biased (F), male-biased (M), or unbiased (U) expression that are X-linked is plotted. (D) Percent of X-linked genes with unbiased expression that are either broadly or narrowly expressed is plotted.
