Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

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Figure 3.
Figure 3.

Genes showing the most significant changes in DNA methylation and gene expression. (A) Three-dimensional starburst plot of 709 genes, integrating significant changes in DNA methylation (x-axis) and gene expression (z-axis), with a mean twofold or greater change in gene expression (y-axis). Colors are as in Figure 2B. (B) Presence of CpG islands and probe locations for genes exhibiting hyper- or hypomethylation and up- or down-regulation. (C) Correlation plots of DNA methylation vs. gene expression in tumors and normal tissues for select genes.

This Article

  1. Published in Advance May 21, 2012, doi: 10.1101/gr.132662.111 Genome Res. 22: 1197-1211

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