Figure 1.
Genetic substructure in the 8p23 inversion region correlates perfectly with inversion status in CEU HapMap II samples. A multidimensional scaling (MDS) analysis based on 5494 SNPs typed in 54 CEU founder members (that satisfied the inclusion criteria; see Methods). The x- and y-axis correspond to the first and second “axes” derived by MDS, and each point represents an individual, labeled by inversion-type (as defined by FISH). (Inset) Tri-modal point distribution found in the first dimension.
