Evolution at the regulatory region of the LRRC37 family. A model for the evolution of promoter regions of LRRC37 is depicted. (A) The LRRC37 family acquired alternative promoter regions, first, from the BPTF promoter region within the macaque lineage; and, second, from the DND1 promoter after the split between New World and Old World monkeys, respectively. An additional promoter, which is amplified from human testis and macaque testis tissues, is detected just upstream of the predicted long coding exon containing the ATG start codon in macaque and human. (B) A schematic representation of the regulation of gene expression within the LRRC37 family. The LRRC37 family evolved from testis-specific expression in mouse to ubiquitous or tissue-specific expression, such as cerebellum and thymus, in human.
