Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region

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Figure 4.
Figure 4.

Luciferase activity assay for promoter regions of the LRRC37 family. (Top panel) Luciferase activity of the ancestral copy of the DND1 promoter region from the (Hs) human (H. sapiens) and (Ptr) chimpanzee (Pan troglodytes) DND1 promoters and a duplicated copy of the promoter regions from the human Chr 17q21.31 H1 haplotype (Hs Chr17 H1-R Cl3 p and Hs Chr17 H1-R Cl3 p), H2 haplotype (Hs Chr17 H2-R Cl3 p and Hs Chr17 H2-R Cl3 p), and PTR chimpanzee (Chr 17 H2 Cl3 p) in HEK293FT cells. (Bottom panel) Schematic representation of H1 and H2 haplotypes on the human genome.

This Article

  1. Published in Advance March 14, 2012, doi: 10.1101/gr.134098.111 Genome Res. 22: 1050-1058

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