Synteny map showing expressed duplicated LRRC37 genes and promoter regions. A synteny map for the LRRC37 family between mouse (mm9), macaque (rheMac2), and human (hg19) genome assembly is prepared using the Ensembl genome browser. The locations of the genes and markers are subsequently confirmed using the UCSC genome browser. The map includes only the actively transcribed LRRC37 genes (red) either reported in sequence databases or detected in our expression analysis. The locations of human LRRC37 genes on the human genome (light blue boxes) are calculated using the first exon of reported mRNA (NM_014834) for LRRC37. We have used the beginning of the LRR region to map LRRC37 genes on macaque chromosome 16 (dark green). Lrrc37 in mouse is mapped using mRNA (AK029868) for Lrrc37 in mouse chromosome 11 (cyan), and the location indicates the beginning of AK029868. The position for the promoter regions Cl3 (green), Cl8 (purple), and testis-specific (light blue) indicate the transcription start point on the respective chromosomes of the species. Arrows show the direction of a gene (5′–3′) or the transcriptional activity of the promoter region for the respective gene. Colored dotted lines connecting genes between different chromosomes indicate a possible common evolutionary history for that individual gene based on phylogenetic analysis. The black colored genes are used as syntenic markers.
