Association between dynamic DNase-seq and differentially expressed genes. Three groups of DHS are represented in LNCaP and MCF-7 cells: hormone-induced DHS sites (red); hormone-unchanged DHS sites (blue); and hormone-diminished DHS sites (green). (Y-axis) Odds ratio calculated by the following formula: (up-regulated genes with at least one nearby site/non-regulated genes with at least one nearby site)/(up-regulated genes with no nearby site/non-regulated genes with no nearby site). In this definition, “nearby” means within 20 kb of the TSS. The hormone-induced sites are associated with up-regulated genes (A), while the hormone-depleted sites are associated with down-regulated genes (B).
