BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration

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Figure 1.
Figure 1.

Oncogenic BRAFV600E remodels the transcriptome in melanoma. (A) Schematic of experimental workflow and RNA-seq data analysis. (B) Pie chart showing number and categories of transcripts regulated by BRAFV600E. Numbers of transcripts changed in all three samples in the same direction ± twofold versus pooled normal melanocyte control. (C) Heatmap showing hierarchical clustering of protein-coding transcript expression in primary melanocytes overexpressing BRAFV600E and in primary melanomas (± twofold, changed in all three samples). (D) Top 10 unique gene ontology (GO) terms associated with protein-coding transcripts up-regulated by BRAFV600E.

This Article

  1. Published in Advance May 11, 2012, doi: 10.1101/gr.140061.112 Genome Res. 22: 1006-1014

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