(A) Inheritance of allelic TF occupancy. The log-ratio of occupancy of the indicated TFs in the maternally versus paternally derived LCLs (y-axis) is plotted against the allelic occupancy of the same factors in GM12878 (x-axis). For each site plotted (N = 85), we required that both parents were homozygous for alternate alleles. Combining all points together, the overall correlation is ρ = 0.75, and for 88% of sites, the more bound allele in GM12878 was also more bound in the corresponding parent. (B) Similar to A, the log-ratio of expression from the parental LCLs plotted as a function of the allelic expression in GM12878. (C) Genes with differential allelic expression have overall lower expression in GM12878. For each gene with expression >0.25 RPKM, the gene expression (y-axis) is shown as a function of differential allelic RNA Pol2 occupancy (x-axis). (Darker shading) Greater density of values; (magenta line) less smoothing over the data.
