Figure 4.
Model of acquisition of drug resistance in Beijing isolates. SNPs conferring drug resistance were mapped onto a cladogram of the Beijing family assuming parsimonious acquisition with no reversion (circles); SNPs are included if the majority of isolates carrying the mutation were phenotypically resistant (Table 3). Applying the same principle, resistance phenotypes with unknown genetic cause were added to the tree (squares; PZA indicates pyrazinamide; KAN, kanamycin; CAP, capreomycin; and FLQ, fluoroquinolones). Genotypes putatively acquired by an inferred common ancestor are boxed in blue.
