Distribution of SNPs according to the Clusters of Orthologous Groups (COG) classification. (U) Intracellular trafficking and secretion; (F) nucleotide transport and metabolism; (V) defense mechanisms; (D) cell cycle control, mitosis, and meiosis; (O) post-translational modification, protein turnover, chaperones; (T) signal transduction mechanisms; (P) inorganic ion transport and metabolism; (H) coenzyme transport and metabolism; (G) carbohydrate transport and metabolism; (K) transcription; (L) replication, recombination, and repair; (E) amino acid transport and metabolism; (C) energy production and conversion; (I) lipid transport and metabolism; (M) cell wall/membrane/envelope biogenesis; (Q) secondary metabolites biosynthesis, transport, and catabolism. (*) Class with significant over-representation of SNPs (p = 0.0015, Binomial test and sequential Bonferroni correction).
