Evolutionary rate covariation reveals shared functionality and coexpression of genes

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Figure 3.
Figure 3.

Galactose enzymes exhibit ERC. The classic galactose metabolic pathway (A) converts galactose (Gal) into glucose 6-phosphate (Glu-6-P) via four enzymes: Gal1p, Gal7p, Gal10p, and Gal5p. A pairwise comparison table (B) shows the strength of ERC (correlation coefficient) between each protein pair. RVC between Gal1p, Gal7p, and Gal10p is notably elevated, while that with Gal5p is less elevated but also positive. ERC between Gal7p and Gal10p is the highest value proteome-wide for both proteins.

This Article

  1. Genome Res. 22: 714-720

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