The TAGteam motif facilitates binding of 21 sequence-specific transcription factors in the Drosophila embryo

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Figure 1.
Figure 1.

Regions bound by many transcription factors frequently contain TAGteam motifs. ChIP-chip data for 21 transcription factors (MacArthur et al. 2009) is plotted across 25 kb near the genes (A) abdominal A (abd-A), (B) sloppy paired 1 (slp1) and sloppy paired 2 (slp2), (C) giant (gt), (D) tailless (tll), (E) short gastrulation (sog), and (F) bicoid (bcd), zerknullt (zen) and zerknullt-related (zen2). (Blue circles) TAGteam motifs CAGGTAG, tAGGTAG, and CAGGTAa; analyses in all figures use only these three TAGteam motifs and their reverse complements. Boxed TAGteam motifs have been previously demonstrated to be required for early expression (ten Bosch et al. 2006; Liberman and Stathopoulos 2009). ChIP data was smoothed as described in Methods. Vertical axes differ between panels for clarity. Gene models are from FlyBase release 5.12 (Tweedie et al. 2009).

This Article

  1. Genome Res. 22: 656-665

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