Genomic organization of Sowah and Irx genes in vertebrates. Schematic representation of the genomic organization of r-Sowah and Sowah (black arrows), Septin (white arrows), and Irx (gray arrows) genes in humans (A) and a generalized teleost (B). Red geometrical shapes represent CNRs within Irx clusters: triangles represent the UltraConserved Regions (UCRs) (de la Calle-Mustienes et al. 2005), and ellipses and rectangles the only two CNRs present within Sowah2 in teleosts. For simplicity, only schematic intron–exon structures are indicated for Sowah1 and Sowah2. (C) VISTA plot of the alignments between IrxB clusters of different vertebrate species, using elephant shark as a reference sequence for the comparison. Colored peaks (blue, coding; turquoise, UTR; pink, noncoding) indicate regions of at least 100 bp and ≥70% similarity. Sowah2-CNRs are demarcated by a red rectangle.
