An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement

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Figure 4.
Figure 4.

Transcriptional enhancer activity of B. floridae sequences from the Irx-Sowah complex. Lateral views of 48-hpf zebrafish showing GFP expression driven by the 5b, 10b, and 10d CNRs. The 5b-driven expression is detected in the spinal cord and in the telencephalon; 10b and 10d consistently drove expression throughout the CNS (midbrain, hindbrain, and spinal cord) and in the eye. Anterior is to the right. (e) eye; (h) hindbrain; (m) midbrain; (s) spinal cord; (t) telencephalon.

This Article

  1. Published in Advance January 10, 2012, doi: 10.1101/gr.132233.111 Genome Res. 22: 642-655

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