Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

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Figure 3.
Figure 3.

Genomic patterns of 5hmC enrichment are tissue-specific. (A) Shown are the patterns of 5hmC enrichment [log2(input/IP)] across the HOXA cluster for multiple replicates of multiple tissues. (B) A dendrogram derived from unsupervised hierarchical consensus clustering of 14 human DNA samples based on 5hmC enrichment levels for all 72,000 probes on each tiling microarray. Samples cluster by tissue type. AU (approximately unbiased) P-value of robustness of each cluster; (**) P > 0.01; (***) P > 0.001.

This Article

  1. Published in Advance November 21, 2011, doi: 10.1101/gr.126417.111 Genome Res. 22: 467-477

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