A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing

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Figure 1.
Figure 1.

Pathology of lung adenocarcinoma analyzed in this study. (A) A paraffin section stained by hematoxylin and eosin from a primary lung cancer tissue obtained by CT-guided biopsy (400×). In the cancer tissue, poorly differentiated tumor cell nests were present in the desmoplastic stroma. In addition, the cancer cells had plump cytoplasm and large pleomorphic nuclei. (B) Immunohistochemical analyses of the cancer (from metastatic tumor in the cervical spine). From left to right, CK7 (positive), TTF1 (positive), and CK20 (negative). The results highly suggest that the origin of this cancer is lung adenocarcinoma.

This Article

  1. Genome Res. 22: 436-445

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