Figure 3.
Top-scoring module in the TCGA serous ovarian cancer data set. (A) The top-scoring module contains five genes: BRCA1, BRCA2, CCNE1, RB1, and RBBP8. (B) RBBP8 is focally amplified in the TCGA ovarian cancer data set. First, overall survival for CCNE1 amplified cases is compared to CCNE1 wild-type cases among BRCA wild-type cases only (C). Then, overall survival for BRCA mutated cases is compared to BRCA wild-type cases among CCNE1 diploid cases only (D). The worst outcome associated with CCNE1 amplification is no longer detectable once BRCA mutated cases are removed. In contrast, patients with BRCA1 or BRCA2 mutated still show a better outcome even when compared among CCNE1 wild type only.
