Figure 1.
Overview of GSAA. Differential gene expression scores are computed for each gene from gene expression profiles (left). Independently, SNP set association scores for each gene are likewise computed based on the SNPs assigned to the respective gene (right). The gene association scores integrate evidence from both the expression signature and the genotype signature for each gene. Finally, the pathway association test identifies gene sets associated with samples of a single phenotype by integrating evidence across genes in the gene sets.
