Figure 6.
Timing. (A) The evolution tree for the rearranged allele of segment 51 from NCI-H209 (see Fig. 3Biv), which undergoes three transformations—a chromosomal duplication and two breakage-fusion-bridge cycles, resulting in four time periods. Each node represents a single genomic segment during a single time period. Three adjacency matrices e1, e2, and e3 are binary representations of the duplication events. The numbers at each node count the number of emanating leaves. These are obtained by matrix multiplication of the adjacency matrices (in reverse order) to the index vector [1,1,1,1,1]. (B) The predicted time line for the NCI-H209 rearrangement cluster.
