Genome-scale analysis of aberrant DNA methylation in colorectal cancer

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Figure 3.
Figure 3.

CIMP-L-associated DNA hypermethylation occurs independent of KRAS mutation status in CRC. CIMP-L and non-CIMP tumors were subdivided by their KRAS and BRAF mutation status (KRAS mutant or BRAF/KRAS wild-type), and mean DNA methylation β-values were compared between each group. Scatterplots comparing mean DNA methylation β-values between (A) KRAS mutant and BRAF/KRAS wild-type tumors within the CIMP-L subgroup; (B) KRAS mutant and BRAF/KRAS wild-type tumors within the non-CIMP subgroups; (C) KRAS mutant, CIMP-L tumors versus KRAS mutant, non-CIMP tumors; and (D) BRAF/KRAS wild-type, CIMP-L tumors compared with non-CIMP tumors with the same genotype.

This Article

  1. Published in Advance June 9, 2011, doi: 10.1101/gr.117523.110 Genome Res. 22: 271-282

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