Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

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Figure 6.
Figure 6.

Large-scale organization of H3K9me3 and H3K27me3. (A) Hypomethylation near the DCC tumor suppressor coincides with H3K9me3, which is flanked by H3K27me3. (B) Hypomethylation near the DLC1 tumor suppressor coincides with H3K9me3, which is flanked by H3K27me3. (C) Enrichment of H3K9me3 within 2 Mb of H3K9me3 domains in HCC1954 and IMR90. (D) Enrichment of H3K27me3 within 2 Mb of H3K9me3 domains in HCC1954 and IMR90. (E) Enrichment of mCG within 2 Mb of H3K9me3 domains in HCC1954 and IMR90. (F) Fraction of H3K9me3 domains flanked by 0, 1, or 2 H3K27me3 domains.

This Article

  1. Published in Advance December 7, 2011, doi: 10.1101/gr.125872.111 Genome Res. 22: 246-258

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