A gene-condition interaction network. A total of 1828 significant genotype–phenotype interactions were scored and visualized in a gene-condition interaction network. Conditions are represented as rounded squares and color-coded as carbon source, stress, or in vivo niche. Genes are color-coded according to their functional category. Interactions between a gene and a condition (nodes) are indicated by a line (edge); blue for a positive interaction (mutant fitness > wild-type), orange for a negative interaction (mutant fitness < wild-type). For both conditions and genes, the size of the node increases with the number of interactions, while the thickness of the line increases with the fitness effect.
