CpG islands and GC content dictate nucleosome depletion in a transcription-independent manner at mammalian promoters

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Figure 5.
Figure 5.

Pol II occupancy influences nucleosome positioning but not nucleosome depletion at CGI promoters. Heat maps of CpG content, nucleosome density, and nucleosome midpoints ordered by increasing GC content are shown for 2590 Pol II–containing (A) and 2590 Pol II–depleted (B) CGI promoters only. CGI border trend lines are shown on the CpG heat maps as for Figure 3A. (C) Corresponding average profiles of subgroups A–F (gene sextiles from lowest to highest GC content) for nucleosome densities and CpG dinucleotide scores are shown.

This Article

  1. Genome Res. 22: 2399-2408

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