Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

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Figure 2.
Figure 2.

Frequently altered genes in lung cancer genomes. (A) The top 20 genes with the highest mutation rates in lung cancer cell lines include three frequently mutated genes (KRAS, TP53, and STK11) in lung tumors from previous studies (Ding et al. 2008). (B) Profiles of single-nucleotide variation and copy number alterations in lung cancer cell lines and tumors for a subset of known cancer-related genes. (C) Profiles of single-nucleotide variation and copy number alterations in lung cancer cell lines and tumors for a subset of genes in epigenetic pathways.

This Article

  1. Published in Advance October 2, 2012, doi: 10.1101/gr.140988.112 Genome Res. 22: 2315-2327

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