Integration of ChIP-seq and machine learning reveals enhancers and a predictive regulatory sequence vocabulary in melanocytes

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Figure 5.
Figure 5.

Putative enhancers direct reporter expression in melanocytes of transgenic zebrafish embryos. (A) Dorsal view of melanocytes on the head of wild-type zebrafish embryo at 3 d post-fertilization (dpf). (B) Same view as A after treatment with epinephrine, which causes contraction of pigment granules to the center of the cell and enables the visualization of GFP at the periphery of melanocytes in transgenic embryos. (C–I) Representative images for all seven enhancers positive in this assay showing GFP-positive melanocytes in transgenic (mosaic) embryos at 3 dpf after treatment with epinephrine. Numbering is consistent with Figure 4.

This Article

  1. Published in Advance September 27, 2012, doi: 10.1101/gr.139360.112 Genome Res. 22: 2290-2301

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