Figure 2.
Experimental validation of tissue-specific enhancer candidates in transgenic zebrafish and mouse assays. Our computational approach trained on small empirical data sets (red bars) resulted in validation rates comparable to those for ChIP-seq-derived data sets using an EP300 antibody (gray bars) for the heart. Similarly, the validation rates of computational Hb classifiers trained on small empirical data sets were also comparable to those obtained with EP300 ChIP-seq experiments in other brain tissues.
