nFuse: Discovery of complex genomic rearrangements in cancer using high-throughput sequencing

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Figure 5.
Figure 5.

CGRs discovered in primary tumor sample 963. (A) A single CCBR produces four fusion genes: MYC-ARHGEF17, ARHGEF17-SHANK2, SHANK2-HMGN2P46, and HMGN2P46-MYC. Only the ARHGEF17-SHANK2 and HMGN2P46-MYC fusion genes produce fusion transcripts. (B) Example of a CGR that is both a CCBR and a polyfusion involving three loci. The aberrant 1-7-11 chromosome produces three fusion transcripts: WDTC1-CD151, WDTC1-EFCAB4A, and WDTC1-PRKRIP1.

This Article

  1. Published in Advance June 28, 2012, doi: 10.1101/gr.136572.111 Genome Res. 22: 2250-2261

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