nFuse: Discovery of complex genomic rearrangements in cancer using high-throughput sequencing

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Figure 4.
Figure 4.

Complex breakpoints and polyfusions in HCC1954. (A–D) Complex breakpoints produce truncated GSDMC and PVT1 transcripts and ENDOD1-WASH2P and ZDHHC11-RNF130 fusion transcripts. Validated by LR-PCR. (E) A PHF20L1-FAM49B-SAMD12 polyfusion produces an in-frame PHF20L1-SAMD12 fusion transcript. Validated by LR-PCR. (F–G) Complex breakpoints corroborated by multiple fusion transcripts.

This Article

  1. Published in Advance June 28, 2012, doi: 10.1101/gr.136572.111 Genome Res. 22: 2250-2261

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