nFuse: Discovery of complex genomic rearrangements in cancer using high-throughput sequencing

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Closed chains of breakage and rejoining (CCBRs). (A) In an idealized version of a CCBR, no chromosomal material is lost or gained. (B) Actual CCBRs may involve small loss or gain of chromosomal material. For instance, the A2→A3 and C2→C3 sections of chromosomes A and C appear to have been lost, and the B2→B3 section of chromosome B appears to have been duplicated. (C) The breakpoint graph for the CCBR in B showing (A1, A4) and (C1, C4) loss edges and a (B2, B3) gain edge.

This Article

  1. Published in Advance June 28, 2012, doi: 10.1101/gr.136572.111 Genome Res. 22: 2250-2261

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research