Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1.
Figure 1.

Enrichment of THP-1 cell ribosomal footprint data for TISs, following puromycin treatment. (A) Polysome profile of the TPP1 gene in control and puromycin-treated THP-1 cells. (B) Pooled read coverage for the 500 most highly expressed genes. Transcript-specific coverage values were normalized to the total number of reads for each gene and the transcript length was scaled to 1000 bp for all RefSeq sequences. (C) Pooled read coverage around the annotated AUG TICs of the 500 most highly expressed genes in puromycin-treated cells.

This Article

  1. Published in Advance August 9, 2012, doi: 10.1101/gr.139568.112 Genome Res. 22: 2208-2218

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research